Early research shows promising signs that a product made from cannabis known as cannabidiol (CBD) oil may help relieve anxiety. CBD is a type of cannabinoid, a chemical found naturally in marijuana and hemp plants. Unlike tetrahydrocannabinol (THC), another type of cannabinoid, CBD doesn’t cause any feelings of intoxication or the “high” you may associate with cannabis. Learn more about the potential benefits of CBD oil for anxiety, and whether it could be a treatment option for you.

CBD oil is thought to work with a brain receptor called CB1. Receptors are tiny proteins attached to your cells that receive chemical signals from different stimuli and help your cells respond.

The exact way CBD affects CB1 is not fully understood. However, it’s thought that it alters serotonin signals. Serotonin is one of your body’s chemicals and plays a role in your mental health. Low serotonin levels are common in depression. Not having enough serotonin can also cause anxiety in some people.

The conventional treatment for low serotonin is prescription selective serotonin reuptake inhibitors (SSRIs). Zoloft and Prozac are both SSRIs. CBD, for some people, may be an alternative to SSRIs for anxiety management. However, you should talk to your doctor before making changes to your treatment plan.

Several studies point to the potential benefits of CBD for anxiety. For generalized anxiety, the National Institute on Drug Abuse says that CBD has been shown to reduce stress in animal studies. Study subjects were observed as having lower behavioral signs of anxiety. Their physiological symptoms of anxiety, like increased heart rate, also improved.

Studies have also shown some benefits for other forms of anxiety, such as social anxiety disorder (SAD) and post-traumatic stress disorder (PTSD). CBD may also help treat anxiety-induced insomnia.

In 2011, a human study on CBD and its effects on SAD was published in the Journal of Psychopharmacology. Participants were given either an oral dose of 400 milligrams of CBD or a placebo. The results showed that those who took the CBD dose experienced overall reduced anxiety levels.

On the other hand, a 2017 comprehensive review of CBD studies in psychiatric disorders found inconclusive results. According to the authors, there isn’t enough evidence to claim CBD as a treatment for depression. However, the authors do note positive results for anxiety disorders. Based on their review, more human tests are needed to better understand how it works, what ideal dosages should be, and if there are potential side effects or hazards.

CBD has also been studied in other neurological disorders. A 2016 study found some antipsychotic benefits of CBD in schizophrenia. The authors indicated a preference for CBD over antipsychotic drugs, which are known to cause significant debilitating side effects.

CBD is generally considered safe. However, some people who take CBD may experience side effects, including:

• gastrointestinal discomfort
• sleeping difficulties
• mood changes
• dry mouth
• dizziness
• fatigue

You shouldn’t stop taking any medications you’re already using without talking to your doctor first. Using CBD oil may help your anxiety, but you could also experience withdrawal symptoms if you suddenly stop taking your prescription medications. Symptoms of withdrawal include:

• irritability
• dizziness
• nausea
• fogginess

Marijuana has been used to treat pain as far back as 2900 B.C. (2).

More recently, scientists have discovered that certain components of marijuana, including CBD, are responsible for its pain-relieving effects.

The human body contains a specialized system called the endocannabinoid system (ECS), which is involved in regulating a variety of functions including sleep, appetite, pain and immune system response (3).

The body produces endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors in your nervous system.

Studies have shown that CBD may help reduce chronic pain by impacting endocannabinoid receptor activity, reducing inflammation and interacting with neurotransmitters (4).

For example, one study in rats found that CBD injections reduced pain response to surgical incision, while another rat study found that oral CBD treatment significantly reduced sciatic nerve pain and inflammation (5, 6).

Several human studies have found that a combination of CBD and THC is effective in treating pain related to multiple sclerosis and arthritis.

An oral spray called Sativex, which is a combination of THC and CBD, is approved in several countries to treat pain related to multiple sclerosis.

In a study of 47 people with multiple sclerosis, those treated with Sativex for one month experienced a significant improvement in pain, walking and muscle spasms, compared to the placebo group (7).

Another study found that Sativex significantly improved pain during movement, pain at rest and sleep quality in 58 people with rheumatoid arthritis (8).

SUMMARYCBD, especially in combination with THC, may be effective in reducing pain associated with diseases like multiple sclerosis and rheumatoid arthritis

Anxiety and depression are common mental health disorders that can have devastating impacts on health and well-being.

According to the World Health Organization, depression is the single largest contributor to disability worldwide, while anxiety disorders are ranked sixth (9).

Anxiety and depression are usually treated with pharmaceutical drugs, which can cause a number of side effects including drowsiness, agitation, insomnia, sexual dysfunction and headache (10).

What’s more, medications like benzodiazepines can be addictive and may lead to substance abuse (11).

CBD oil has shown promise as a treatment for both depression and anxiety, leading many who live with these disorders to become interested in this natural approach.

In one study, 24 people with social anxiety disorder received either 600 mg of CBD or a placebo before a public speaking test.

The group that received the CBD had significantly less anxiety, cognitive impairment and discomfort in their speech performance, compared to the placebo group (12).

CBD oil has even been used to safely treat insomnia and anxiety in children with post-traumatic stress disorder (13).

CBD has also shown antidepressant-like effects in several animal studies (14, 15).

These qualities are linked to CBD’s ability to act on the brain’s receptors for serotonin, a neurotransmitter that regulates mood and social behavior.

SUMMARYUsing CBD has been shown to reduce anxiety and depression in both human and animal studies.

CBD may help reduce symptoms related to cancer and side effects related to cancer treatment, like nausea, vomiting and pain.

One study looked at the effects of CBD and THC in 177 people with cancer-related pain who did not experience relief from pain medication.

Those treated with an extract containing both compounds experienced a significant reduction in pain compared to those who received only THC extract (16).

CBD may also help reduce chemotherapy-induced nausea and vomiting, which are among the most common chemotherapy-related side effects for those with cancer (17).

Though there are drugs that help with these distressing symptoms, they are sometimes ineffective, leading some people to seek alternatives.

A study of 16 people undergoing chemotherapy found that a one-to-one combination of CBD and THC administered via mouth spray reduced chemotherapy-related nausea and vomiting better than standard treatment alone (18).

Some test-tube and animal studies have even shown that CBD may have anticancer properties. For example, one test-tube study found that concentrated CBD induced cell death in human breast cancer cells (19).

Another study showed that CBD inhibited the spread of aggressive breast cancer cells in mice (20).

However, these are test-tube and animal studies, so they can only suggest what might work in people. More studies in humans are needed before conclusions can be made.

SUMMARYThough CBD has been shown to help reduce symptoms related to cancer and cancer treatment, and may even have cancer-fighting properties, more research is needed to assess its efficacy and safety.